Description:
Scientist I, Oligonucleotide Analytics
Key Responsibilities:
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
Role is 100% onsite
No
Additional Details
|
...-time Pay : $60,,000 Benefits : 401(k), Dental Insurance, Disability Insurance, Flexible schedule, Health Insurance, Life Insurance, Paid time off, Vision Insurance... ...: CPA License (Preferred) Work Location : Remote / Hybrid / On-Sight To be considered, please apply...
...3:15pm-12:00am~Previous woodshop exp (min 6months)~Previous exp. with power tools (I.E saw/automatic joiner/staple gun/air compressor)~Fluent in english~Ability to perform adn understand basic math~**must be proficient with a tape measure~**must be able...
...we invite you to join our dynamic team. Job Title: Sweeper Truck Driver Job Summary: The CDL Sweeper Truck Driver operates a Broom... ...on scheduled routes, clearing debris such as broken pavement, concrete millings, mud, and construction materials. This includes new...
...Do you love unique, off-the-beaten-path adventures? We are onboarding Adventure & Specialty Travel Planners to design trips that include safaris, eco-tourism, cultural tours, and adventure sports. This role is perfect for those who love variety and want to inspire clients...
...Aramark Student Nutrition provides food and nutrition services to over 350 school districts in the U.S. It offers public and private education... ...visit Aramark Student Nutrition . The Food Service Director is a management position responsible for developing and executing...